Biogenic selenium nanoparticles: current status and future prospects

Wadhwani, Sweety A.; Shedbalkar, Utkarsha U.; Singh, Richa; Chopade, Balu A.

doi:10.1007/s00253-016-7300-7

Biogenic selenium nanoparticles: current status and future prospects

Authors

Sweety A. Wadhwani

Utkarsha U. Shedbalkar

Richa Singh

Balu A. Chopade

Published

January 22, 2016

Abstract

Selenium nanoparticles (SeNPs) are gaining importance in the field of medicine owing to their antibacterial and anticancer properties. SeNPs are biocompatible and non-toxic compared to the counterparts, selenite (SeO3 −2) and selenate (SeO4 −2). They can be synthesized by physical, chemical, and biological methods and have distinct bright orange-red color. Biogenic SeNPs are stable and do not aggregate owing to natural coating of the biomolecules. Various hypotheses have been proposed to describe the mechanism of microbial synthesis of SeNPs. It is primarily a two-step reduction process from SeO4 −2 to SeO3 −2 to insoluble elemental selenium (Se0) catalyzed by selenate and selenite reductases. Phenazine-1-carboxylic acid and glutathione are involved in selenite reduction. Se factor A (SefA) and metalloid reductase Rar A present on the surface of SeNPs confer stability to the nanoparticles. SeNPs act as potent chemopreventive and chemotherapeutic agents. Conjugation with antibiotics enhances their anticancer efficacy. These also have applications in nanobiosensors and environmental remediation.

Wadhwani SA, Shedbalkar UU, Singh R, Chopade BA (2016). Applied Microbiology and Biotechnology 100(6): 2555–2566.

https://doi.org/10.1007/s00253-016-7300-7

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Citation

BibTeX citation:

@article{wadhwani2016,
  author = {Wadhwani, Sweety A. and Shedbalkar, Utkarsha U. and Singh,
    Richa and Chopade, Balu A.},
  title = {Biogenic Selenium Nanoparticles: Current Status and Future
    Prospects},
  journal = {Applied Microbiology and Biotechnology},
  volume = {100},
  number = {6},
  pages = {2555-2566},
  date = {2016-01-22},
  url = {https://drrichasingh.in/papers/2016-biogenic-senp-review.html},
  doi = {10.1007/s00253-016-7300-7},
  issn = {1432-0614},
  langid = {en},
}

For attribution, please cite this work as:

Wadhwani, Sweety A.; Shedbalkar, Utkarsha U.; Singh, Richa; Chopade, Balu A. 2016. Biogenic selenium nanoparticles: current status and future prospects. Applied Microbiology and Biotechnology 100 (6): 2555–66. https://doi.org/10.1007/s00253-016-7300-7.