Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications

Authors

Richa Singh

Utkarsha U. Shedbalkar

Sweety A. Wadhwani

Balu A. Chopade

Published

May 9, 2015

Abstract
Silver nanoparticles (AgNPs) have received a tremendous attention due to their significant antimicrobial properties. Large numbers of reports are available on physical, chemical and biological synthesis of colloidal AgNPs. Since there is a great need to develop ecofriendly and sustainable methods, biological systems like bacteria, fungi and plants are being employed to synthesize these nanoparticles. The present review focuses specifically on bacterial-mediated synthesis of AgNPs, its mechanism and applications. Bacterial synthesis of extra- and intra-cellular AgNPs have been reported using biomass, supernatant, cell-free extract and derived components. Extracellular mode of synthesis is preferred over intracellular mode owing to easy recovery of nanoparticles. Silver-resistant genes, c-type cytochromes, peptides, cellular enzymes like nitrate reducatse and reducing cofactors play significant roles in AgNP synthesis in bacteria. Organic material released by bacteria act as natural capping and stabilizing agents for AgNPs, thereby, preventing their aggregation and providing stability for a longer time. Regulation over reaction conditions has been suggested to control the morphology, dispersion and yield of nanoparticles. Bacterial AgNPs have anticancer and antioxidant property. Moreover, antimicrobial activity of AgNPs in combination with antibiotics signifies their importance in combating the multidrug-resistant pathogenic microorganisms. Multiple microbicidal mechanisms exhibited by AgNPs, depending upon their size and shape, make them very promising as novel nano-antibiotics.

Applied Microbiology and Biotechnology 99(11): 4579-4593 (2015).

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https://doi.org/10.1007/s00253-015-6622-1

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Citation

BibTeX citation:
@article{singh2015,
  author = {Singh, Richa and Shedbalkar, Utkarsha U. and Wadhwani,
    Sweety A. and Chopade, Balu A.},
  title = {Bacteriagenic Silver Nanoparticles: Synthesis, Mechanism, and
    Applications},
  journal = {Applied Microbiology and Biotechnology},
  volume = {99},
  number = {11},
  pages = {4579-4593},
  date = {2015-05-09},
  url = {https://drrichasingh.in/papers/2015-bacteriagenic-agnp-review.html},
  doi = {10.1007/s00253-015-6622-1},
  issn = {1432-0614},
  langid = {en},
}
For attribution, please cite this work as:
Singh, Richa; Shedbalkar, Utkarsha U.; Wadhwani, Sweety A.; Chopade, Balu A. 2015. Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications. Applied Microbiology and Biotechnology 99 (11): 4579–93. https://doi.org/10.1007/s00253-015-6622-1.